Spontaneous DNA Damage Stimulates Topoisomerase II-mediated DNA Cleavage
نویسندگان
چکیده
منابع مشابه
Ultraviolet-induced DNA Damage Stimulates Topoisomerase
An antibody-based method was used to examine genomic DNA cleavage by endogenous topoisomerases in living cells. The method quantifies cleavable (covalent) complex formation in vivo after exposure to topoisomerase poisons, as reported previously (D. Subramanian et al., Cancer Res., 55: 2097-2103, 1995). Unexpectedly, exposing cells to UVB irradiation stim ulated endogenous topoisomerase I-DNA co...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.11.7488